Journal article
Etiology of Hypomineralized Second Primary Molars: A Prospective Twin Study
MJ Silva, NM Kilpatrick, JM Craig, DJ Manton, P Leong, D Burgner, KJ Scurrah
Journal of Dental Research | SAGE PUBLICATIONS INC | Published : 2019
Abstract
The etiology of hypomineralized second primary molars (HSPM) is unclear, but genetic and environmental factors have been proposed. The aim of this study was to investigate the relative contribution of genes and environment to the etiology of HSPM and to identify potential environmental risk factors in a longitudinal twin cohort. Children from twin pregnancies (N = 250) were recruited antenatally, and detailed demographic, health, and phenotypic data were collected at recruitment, 24- and 36-wk gestation, birth, and 18 mo of age. 25-Hydroxyvitamin D was quantified for mothers at 28-wk gestation and infants at birth. Dental examinations were conducted on the twins at 6 y of age to determine th..
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Awarded by National Institute of Dental and Craniofacial Research
Funding Acknowledgements
We wish to thank all twins and their families, as well as Richard Saffery, Tina Vaiano, Jane Loke, Anna Czajko, Chrissie Robinson, Hillary Ho, and Supriya Raj for their expertise and assistance. The research in this publication was supported by the National Institute of Dental and Craniofacial Research of the National Institutes of Health under grant R01DE019665. The Peri/postnatal Epigenetic Twins Study was supported by grants from the Australian National Health and Medical Research Council (grants 437015 and 607358), the Bonnie Babes Foundation (grant BBF20704), the Financial Markets Foundation for Children (grant 032-2007), the Victorian Government's Operational Infrastructure Support Program, the Australian and New Zealand Society for Paediatric Dentistry Victorian Branch, and the University of Melbourne Paediatric Dentistry Fund. M.J.S. is supported by an National Health and Medical Research Council Postgraduate Health Research Scholarship. K.J.S. is supported by a Centre of Research Excellence grant in Twin Research and a National Health and Medical Research Council project grant (1084197). The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.